Difference between revisions of "Phage therapy"

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'''The isolation, characterization and pre-clinical screening of novel bacteriophages as therapies for antibiotic resistant, sexually-transmitted bacterial infections'''.
'''The isolation, characterization and pre-clinical screening of novel bacteriophages as therapies for antibiotic resistant, sexually-transmitted bacterial infections'''.


''Next Call: 1/20/12 8:00pm PST/10:00pm CST'' (meeting notes are available [https://pad.riseup.net/p/phage_therapy here]).
''Next Call: 1/27/13 8:00pm PST/10:00pm CST''
 
'''Social Project Goals''':
 
*Create and foster an open access citizen science project that accomplishes specific project goals while educating and nurturing community scientific creativity.
 
*'''Community Agreements'''
''We are non-hierarchical'': We recognize the outcomes of hierarchy. Hierarchy represses creative thought in science,
denies access to science, and holds back global scientific development. As a community of citizen scientists working
toward a more complete understanding of molecular medicine, we commit ourselves to nurturing creative, positive voices
within our community. We commit ourselves to hearing everyone and refuse to acknowledge hierarchy based on: sex and
gender; race; age; accreditation; education; class; or access to resources. We will stand in solidarity against
oppression and hierarchy.
 
''Open Access and transparency'': Everyone is invited to participate in and learn from this project. We will always
make time for conversation and teaching opportunities. Online meetings, communications regarding this project, and
all findings will be publicized on this fully-editable wiki with the stipulation that those participating adhere to
a value system of mutual '''respect''', '''safety and understanding'''; while accepting that these values will be
'''enforced via community-based decision making'''.
 
''Decision-making'': '''Consensus'''; we believe scientists should be open to discussion around research experiments,
and directions. To foster a spirit of openness and understanding, no decision will be made without 100% consensus.  
 
''Answering Questions'': Our social goal is the pursuit of medical knowledge, we are not approaching this project with
the hope of making money; we want to answer questions - collectively- and serve humanity. We will stand in solidarity
against anyone who chooses to co-opt or privatize any portion of this project. All knowledge must be '''free and accessible'''!
 


'''Discussion Topics Include''':
*Introduction into the project
*Discussion of organizational (non-hierarchical) structure
*Introduction to molecular genetics of Phage (lytic vs. lysogenic)
* Lytic phage kill; Lysogenic incorporate in host genome then wait for opportunity to become lytic!
* Lysogenic phage are induced (UV light, chemicals) and prophage DNA is excised, phage are created, bacteria lyse!
*Methods of Phage Isolation and Characterization
*"Isolation and Characterization of Bacteriophages for Neisseria" L.N. Phelps, J. gen. Virol (1967) 1, 529-532.
*Molecular Manipulation of Phage
*Molecular Biology and Immunology of target organisms.