Phage therapy

The isolation, characterization and pre-clinical screening of novel bacteriophages as therapies for antibiotic resistant, sexually-transmitted bacterial infections.

Next Call: 1/20/12 8:00pm PST/10:00pm CST

Discussion Topics Include:

• Introduction into the project
• Discussion of organizational (non-hierarchical) structure
• Introduction to molecular genetics of Phage (lytic vs. lysogenic)

* Lytic phage kill; Lysogenic incorporate in host genome then wait for opportunity to become lytic!
* What if we could activate phage lytic life cycle with non-antibiotic molecules?
    * Quorum Sensing [1]

• Methods of Phage Isolation and Characterization

*"Isolation and Characterization of Bacteriophages for Neisseria" L.N. Phelps, J. gen. Virol (1967) 1, 529-532.

• Molecular Manipulation of Phage
• Molecular Biology and Immunology of target organisms.

if you'd like to attend the conference call, please contact: Craig Rouskey (craigrouskey [at] gmail [dot] com)

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Relevance

http://www.smithsonianmag.com/science-nature/phenom_oct00.html?c=y&page=1

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Here are some videos to review

http://www.youtube.com/watch?v=LiPZq2K_Tos&NR=1&feature=endscreen

http://www.youtube.com/watch?v=ehbZpo8oXSs

http://www.youtube.com/watch?v=3VjE1zddXWk

http://www.youtube.com/watch?v=ZENpYdQg-z4

http://www.youtube.com/watch?v=egY-Br_oTHE

http://www.youtube.com/watch?v=Oms5SA_4-kE

http://www.youtube.com/watch?v=3eQhNyX7DRQ

http://www.youtube.com/watch?v=lUcMGktSc7c&NR=1&feature=endscreen