The isolation, characterization and pre-clinical screening of novel bacteriophages as therapies for antibiotic resistant, sexually-transmitted bacterial infections.
Next Call: 1/20/12 8:00pm PST/10:00pm CST (meeting notes available here.)
Discussion Topics Include:
- Introduction into the project
- Discussion of organizational (non-hierarchical) structure
- Introduction to molecular genetics of Phage (lytic vs. lysogenic)
* Lytic phage kill; Lysogenic incorporate in host genome then wait for opportunity to become lytic! * Lysogenic phage are induced (UV light, chemicals) and prophage DNA is excised, phage are created, bacteria lyse!
- Methods of Phage Isolation and Characterization
*"Isolation and Characterization of Bacteriophages for Neisseria" L.N. Phelps, J. gen. Virol (1967) 1, 529-532.
- Molecular Manipulation of Phage
- Molecular Biology and Immunology of target organisms.
if you'd like to attend the conference call, please contact: Craig Rouskey (craigrouskey [at] gmail [dot] com)
Relevance
http://www.smithsonianmag.com/science-nature/phenom_oct00.html?c=y&page=1
Here are some videos to review
http://www.youtube.com/watch?v=LiPZq2K_Tos&NR=1&feature=endscreen
http://www.youtube.com/watch?v=ehbZpo8oXSs
http://www.youtube.com/watch?v=3VjE1zddXWk
http://www.youtube.com/watch?v=ZENpYdQg-z4
http://www.youtube.com/watch?v=egY-Br_oTHE
http://www.youtube.com/watch?v=Oms5SA_4-kE
http://www.youtube.com/watch?v=3eQhNyX7DRQ
http://www.youtube.com/watch?v=lUcMGktSc7c&NR=1&feature=endscreen