Difference between revisions of "Phage therapy"
→History of Phage Therapy
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:D'Herelle first observed bacteriophages studying microbiologic means of controlling an epizootic of locusts in Mexico in 1910. He later used his observations bacteriophages to perform one of the first phage therapy techniques known on severe hemorrhagic dysentery outbreaks among French soldiers stationed at Maisons-Laffitte in the summer of 1915. At Maisons-Laffitte, d'Herelle made bacterium-free filtrates of the patients' fecal samples and mixed and incubated them with Shigella strains isolated from the patients. A portion of the mixtures was inoculated into experimental animals (as part of d'Herelle's studies on developing a vaccine against bacterial dysentery), and a portion was spread on agar medium in order to observe the growth of the bacteria. It was on these agar cultures that d'Herelle observed the appearance of small, clear areas, which he initially called taches, then taches vierges, and, later, plaques [68]. His findings were presented in September 1917 meeting of the Academy of Sciences and later published [18]. | :D'Herelle first observed bacteriophages studying microbiologic means of controlling an epizootic of locusts in Mexico in 1910. He later used his observations bacteriophages to perform one of the first phage therapy techniques known on severe hemorrhagic dysentery outbreaks among French soldiers stationed at Maisons-Laffitte in the summer of 1915. At Maisons-Laffitte, d'Herelle made bacterium-free filtrates of the patients' fecal samples and mixed and incubated them with Shigella strains isolated from the patients. A portion of the mixtures was inoculated into experimental animals (as part of d'Herelle's studies on developing a vaccine against bacterial dysentery), and a portion was spread on agar medium in order to observe the growth of the bacteria. It was on these agar cultures that d'Herelle observed the appearance of small, clear areas, which he initially called taches, then taches vierges, and, later, plaques [68]. His findings were presented in September 1917 meeting of the Academy of Sciences and later published [18]. | ||
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===Modern day Phage Therapy in Mammals=== | |||
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===Modern day Phage Therapy in Humans=== | |||
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