Difference between revisions of "Phage therapy"

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96 bytes added ,  08:10, 25 July 2013
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:b. Provide in-the-lab training and experience for those with the desire to pursue citizen science.
:b. Provide in-the-lab training and experience for those with the desire to pursue citizen science.


== Anticipated Problems and Solutions ==
== Anticipated Challenges to Our Approach ==


Key issues that need to be addressed. Table _ shown is a list of problems and solutions that are needed to address our research into phage therapy.
#rapid clearance of phages by human host and bacteria: bacterial strain resistance / anti-phage antibodies.
 
#patient safety: altering phage to prevent lysis of gram negative species.
#rapid clearance of phages
#bacterium targeting and optimization: altering the binding kinetics of Phage adherence.
#patient safety
#bacterium targeting and optimization
#bacterial strains resistance/ anti-phage antibodies
#spread of bacterial resistance
#narrow range of hosts
#narrow range of hosts
#phage purity and purification technique (while administering directly may be hazardous if not bacteria is removed)
#achieving phage purity: while administering directly may be hazardous if bacteria is not removed.
#poor stability of phage
#poor stability of phage: how do we preserve phage ex vivo and ensure that is viable upon administration?
#poor scientific style/methods of past research
#Addressing previous citizen science failures and conducting research with a greater adherence to quality.
#lysogeny
#Preventing Lysogeny.


== Experiments ==
== Experiments ==
57

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