Difference between revisions of "Phage therapy"

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To meet the needs of a rapidly changing public health field in which traditional antibiotic-based therapies are becoming ineffective, the Gonorrhea Eradication Team and Integration Task-force (GETit) was created. This organization was created to conduct research into bacteriophage associated with Neisseria gonorrhoeae. Bacteriophage are viruses that infect bacterial hosts and can induce lysis upon infection. Ultimately, our goal is to identify and characterize bacteriophage from wild type ARNG and use a composite cocktail of ARNG-associated phage as therapy to treat hosts infected with this pathogen.
To meet the needs of a rapidly changing public health field in which traditional antibiotic-based therapies are becoming ineffective, the Gonorrhea Eradication Team and Integration Task-force (GETit) was created. This organization was created to conduct research into bacteriophage associated with Neisseria gonorrhoeae. Bacteriophage are viruses that infect bacterial hosts and can induce lysis upon infection. Ultimately, our goal is to identify and characterize bacteriophage from wild type ARNG and use a composite cocktail of ARNG-associated phage as therapy to treat hosts infected with this pathogen.


During our pilot program, we plan to '''
During our pilot program, we plan to:
# isolate ''N. gonorrhoeae'' from 10 patients
'''# isolate ''N. gonorrhoeae'' from 10 patients
# isolate bacteriophage from 10 clinical samples of ARNG  
# isolate bacteriophage from 10 clinical samples of ARNG  
# characterize bacteriophages from antibiotic-resistant, sexually-transmitted, ''Neisseria gonorrhoeae'', and  
# characterize bacteriophages from antibiotic-resistant, sexually-transmitted, ''Neisseria gonorrhoeae'', and  
# conduct proof-of-concept experiments in which ARNG-derived phage cocktails are used to lyse cultures of ARNG ''in vitro''.'''
# conduct proof-of-concept experiments in which ARNG-derived phage cocktails are used to lyse cultures of ARNG ''in vitro''.'''
 
:
<br />
: This project is in its early stages. Our longer-term goals are to:
: This project is in its early stages. Our longer-term goals are to:
# Begin a free-Gonorrhea screening program on the streets of Oakland and San Francisco;
# Begin a free-Gonorrhea screening program on the streets of Oakland and San Francisco;
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