[sudo-discuss] Multiple monitors setup

Hello Sudoers, I've got a couple of questions for you savvy hackers on the list. I'm looking to setup some multiple monitors stations, both at my place and eventually at sudo room for data analysis, stats, and AI projects. Firstly, can anybody recommend a Linux-based program that handles multiple monitors well? I've been using LXDE in Lubuntu, and am reluctant to use Unity/Ubuntu, but I'd conceivably make a switch to a different display manager if I had to... Secondly, does anybody have experience setting up >2 monitors for one machine, without using more than 1 graphics card, in any OS/display manager? still not able to figure out how exactly to best proceed, and would appreciate hearing from someone with more experience. Thanks, Sam